Journal Title

Reproductive Toxicology

Carleton Author

Walser-Kuntz, Debby

Department

Biology

Year

2007

Publisher

Elsevier

File Name

029_Walser-Kuntz-Debby_InVivoEffectsOfBisphenolAInLaboratoryRodentStudies.pdf

Keywords

Behavior; Neuroendocrine; Endocrine Disruptors; Immune System; Metabolism; Mouse; Rat; Reproduction

Abstract

Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/kg/day, in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10 to 1,000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low-dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long-lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

Rights Management

Yes

RoMEO Color

RoMEO_Color_Green

Preprint Archiving

Yes (with link to journal home page)

Postprint Archiving

Yes

Publisher PDF Archiving

No

Contributing Organization

Carleton College

Type

Article

Format

application/pdf

Included in

Biology Commons

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