Department
Biology
Journal Title
Reproductive Toxicology
Publication Date
2007
Volume No.
24
Issue No.
2
First Page
199
Last Page
224
Publisher
Elsevier
File Name
029_Walser-Kuntz-Debby_InVivoEffectsOfBisphenolAInLaboratoryRodentStudies.pdf
Keywords
Behavior; Neuroendocrine; Endocrine Disruptors; Immune System; Metabolism; Mouse; Rat; Reproduction
Abstract
Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/kg/day, in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10 to 1,000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low-dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long-lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.
Rights Management
Carleton College does not own the copyright to this work and the work is available through the Carleton College Library following the original publisher's policies regarding self-archiving. For more information on the copyright status of this work, refer to the current copyright holder.
RoMEO Color
Green
Preprint Archiving
Yes (with link to journal home page)
Postprint Archiving
Yes
Publisher PDF Archiving
No
Paid OA Option
Yes
Contributing Organization
Carleton College
Type
Article
Format
application/pdf
Language
English
Recommended Citation
Richter, Catherine A., Linda S. Birnbaum, Francesca Farabollini, Retha R. Newbold, Beverly S. Rubin, Chris E. Talsness, John G. Vandenbergh, Debby R. Walser-Kuntz, and Frederick S. vom Saal. 2007. "In Vivo Effects of Bisphenol A in Laboratory Rodent Studies." Reproductive Toxicology 24, (2): 199-224. Accessed via Faculty Work. Biology. Carleton Digital Commons. https://digitalcommons.carleton.edu/biol_faculty/3
