Role of p300/CBP Histoneacetyltransferase Activity in Long Term Memory Formation of the Hippocampus
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epigenetics, long term memory, histone acetylation, fear conditioFear-based anxiety disorders such as Post-Traumatic Stress Disorder (PTSD) consist of symptoms of dysregulated fear memories that get stored as long-term memory (LTM). These long lasting memories affect everyday encounters, even within contexts that would not normally induce fear (Kwapis and Wood., 2014). While it is normal for people to associate a certain environment with fear for a short period of time, people with PTSD form long term memories of a conditioned fear, causing a more detrimental effect on their lives. Short term and LTM formation include distinct mechanistic phases of synaptic plasticity. Specific proteins are synthesized to induce LTM synapses to form with a greater increase in specific neurotransmitter transmission (Guan et al., 2009). This paper will examine the link between epigenetic mechanisms and increased synaptic plasticity in forming LTM formation based on contextual fear conditioning. As we will see, these mechanisms cause certain fear associations to alter the expression of memory-related genes.ning
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