Role of p300/CBP Histoneacetyltransferase Activity in Long Term Memory Formation of the Hippocampus
Individual author or multiple authors
Individual
Major
Biology (BIOL)
Category of Work
Comps
Additional Category of Work
None
Degree
Bachelor of Arts
Class Year
2017
Department or Program
Biology
Comps Adviser(s)
Zweifel, Stephan
Identifier (Includes All Files and Enter All Their Files Name)
changc_2017_BIOL_paper.pdf, changc_2017_BIOL_ppt.pptx
Keywords
epigenetics, long term memory, histone acetylation, fear conditioFear-based anxiety disorders such as Post-Traumatic Stress Disorder (PTSD) consist of symptoms of dysregulated fear memories that get stored as long-term memory (LTM). These long lasting memories affect everyday encounters, even within contexts that would not normally induce fear (Kwapis and Wood., 2014). While it is normal for people to associate a certain environment with fear for a short period of time, people with PTSD form long term memories of a conditioned fear, causing a more detrimental effect on their lives. Short term and LTM formation include distinct mechanistic phases of synaptic plasticity. Specific proteins are synthesized to induce LTM synapses to form with a greater increase in specific neurotransmitter transmission (Guan et al., 2009). This paper will examine the link between epigenetic mechanisms and increased synaptic plasticity in forming LTM formation based on contextual fear conditioning. As we will see, these mechanisms cause certain fear associations to alter the expression of memory-related genes.ning
Access
Access restricted to Carleton College faculty or their designees and staff of Institutional Research & Assessment, access controlled by Carleton username and password.
Student Work Completed Date
1905-07-09
Format
application/pdf, application/ppt
Files Uploaded
Text (paper), Presentation
Rights Management
Student author/s retain copyright to this work. Through online submission process, author/s granted Carleton College the non-exclusive rights to preserve this work as part of Carleton's academic history and to use it for teaching purposes and/or institutional research and assessment.
