Title

Role of p300/CBP Histoneacetyltransferase Activity in Long Term Memory Formation of the Hippocampus

Date of Graduation

2017

Date of Submission

Wed, 01 Mar 2017 04:32:38 GMT

Class Year

2017

Major

Biology (BIOL)

Other Department or Program

Biology

Comps Adviser(s)

Zweifel, Stephan

Category of Work

Comps

Group or Individual

Individual

Degree

Bachelor of Arts

Components of Work

Text (paper), Presentation

Identifier (Includes All Files and Enter All Their Files Name)

changc_2017_BIOL_paper.pdf; changc_2017_BIOL_ppt.pptx

Keywords

epigenetics; long term memory; histone acetylation; fear conditioFear-based anxiety disorders such as Post-Traumatic Stress Disorder (PTSD) consist of symptoms of dysregulated fear memories that get stored as long-term memory (LTM). These long lasting memories affect everyday encounters, even within contexts that would not normally induce fear (Kwapis and Wood., 2014). While it is normal for people to associate a certain environment with fear for a short period of time, people with PTSD form long term memories of a conditioned fear, causing a more detrimental effect on their lives. Short term and LTM formation include distinct mechanistic phases of synaptic plasticity. Specific proteins are synthesized to induce LTM synapses to form with a greater increase in specific neurotransmitter transmission (Guan et al., 2009). This paper will examine the link between epigenetic mechanisms and increased synaptic plasticity in forming LTM formation based on contextual fear conditioning. As we will see, these mechanisms cause certain fear associations to alter the expression of memory-related genes.ning

Access

Access restricted to Carleton College faculty or their designees and staff of Institutional Research & Assessment; access controlled by Carleton username and password.

Student Work Completed Date

1905-07-09

Format

application/pdf; application/ppt

Rights Management

Student author/s retain copyright to this work. Through online submission process, author/s granted Carleton College the non-exclusive rights to preserve this work as part of Carleton's academic history and to use it for teaching purposes and/or institutional research & assessment.

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