Zincâ€© Finger â€©Nucleases:â€© Theâ€© Keyâ€© to â€©CCR5 â€©Gene â€©Disruptionâ€© andâ€© Consequent â€©HIV â€©Eradication
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Bachelor of Arts
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Mitra, Raka; Walser-Kuntz, Debby
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Zinc finger nuclease, sequence â€©specificâ€© endonuclease, CCR5 co-receptor, CXCR4 co-receptor, CCR5 gene disruption, humanâ€© immunodeficiency â€©virusâ€© (HIV), gene therapy, genome editing, HIV-1 M-tropic virus, CD4+ T cells, hematopoieticâ€© stemâ€© cellâ€© transplantationâ€© (SCT), CCR5Î”â€©32 â€©homozygous mutation, zinc finger protein, FokI â€©restrictionâ€© enzyme, modular assembly, oligomerized â€©poolâ€© engineering â€©(OPEN), siteâ€specific â€©doubleâ€strandedâ€© break, nonâ€homologousâ€© endâ€© joiningâ€© (NHEJ), production â€©of â€©a â€©nonâ€functional â€©protein, selective â€©growthâ€© advantage, ZFN-mediated gene â€©disruption, protection from HIV-1 â€©infection, humanizedâ€© mouse â€©modelâ€© of â€©HIV â€©infection, adoptiveâ€© transfer, ex â€©vivo â€©modificationâ€© of â€©CD4+â€©Tâ€©cells, HIVâ€resistantâ€© population, viral load, CD4 count, humanâ€© hematopoietic â€©stem â€©cells â€©(HSCs), combinedâ€© disruptionâ€© ofâ€© both â€©CCR5 â€©and â€©CXCR4, Phase â€©Iâ€© human â€©clinical â€©trial, permanently â€©modifiedâ€© cells
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