Title

Zinc
 Finger 
Nucleases:
 The
 Key
 to 
CCR5 
Gene 
Disruption
 and
 Consequent 
HIV 
Eradication

Major

Biology (BIOL)

Category of Work

Comps

Group or Individual

Individual

Degree

Bachelor of Arts

Class Year

2013

Date of Submission

Tue, 26 Feb 2013 06:36:20 GMT

Year of Graduation

2013

Other Department or Program

Biology

Comps Adviser(s)

Mitra, Raka ; Walser-Kuntz, Debby

Components of Work

Text (paper)

Identifier (Includes All Files and Enter All Their Files Name)

doyleb_2013_BIOL.pdf

Keywords

Zinc finger nuclease; sequence 
specific
 endonuclease; CCR5 co-receptor; CXCR4 co-receptor; CCR5 gene disruption; human
 immunodeficiency 
virus
 (HIV); gene therapy; genome editing; HIV-1 M-tropic virus; CD4+ T cells; hematopoietic
 stem
 cell
 transplantation
 (SCT); CCR5Δ
32 
homozygous mutation; zinc finger protein; FokI 
restriction
 enzyme; modular assembly; oligomerized 
pool
 engineering 
(OPEN); site‐specific 
double‐stranded
 break; non‐homologous
 end
 joining
 (NHEJ); production 
of 
a 
non‐functional 
protein; selective 
growth
 advantage; ZFN-mediated gene 
disruption; protection from HIV-1 
infection; humanized
 mouse 
model
 of 
HIV 
infection; adoptive
 transfer; ex 
vivo 
modification
 of 
CD4+
T
cells; HIV‐resistant
 population; viral load; CD4 count; human
 hematopoietic 
stem 
cells 
(HSCs); combined
 disruption
 of
 both 
CCR5 
and 
CXCR4; Phase 
I
 human 
clinical 
trial; permanently 
modified
 cells

Access

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Student Work Completed Date

2013-02-13

Format

application/pdf

Rights Management

Student author/s retain copyright to this work. Through online submission process, author/s granted Carleton College the non-exclusive rights to preserve this work as part of Carleton's academic history and to use it for teaching purposes and/or institutional research & assessment.

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