Title

Zinc
 Finger 
Nucleases:
 The
 Key
 to 
CCR5 
Gene 
Disruption
 and
 Consequent 
HIV 
Eradication

Date of Graduation

2013

Date of Submission

Tue, 26 Feb 2013 06:36:20 GMT

Class Year

2013

Major

Biology (BIOL)

Other Department or Program

Biology

Comps Adviser(s)

Mitra, Raka ; Walser-Kuntz, Debby

Category of Work

Comps

Group or Individual

Individual

Degree

Bachelor of Arts

Components of Work

Text (paper)

Identifier (Includes All Files and Enter All Their Files Name)

doyleb_2013_BIOL.pdf

Keywords

Zinc finger nuclease; sequence 
specific
 endonuclease; CCR5 co-receptor; CXCR4 co-receptor; CCR5 gene disruption; human
 immunodeficiency 
virus
 (HIV); gene therapy; genome editing; HIV-1 M-tropic virus; CD4+ T cells; hematopoietic
 stem
 cell
 transplantation
 (SCT); CCR5Δ
32 
homozygous mutation; zinc finger protein; FokI 
restriction
 enzyme; modular assembly; oligomerized 
pool
 engineering 
(OPEN); site‐specific 
double‐stranded
 break; non‐homologous
 end
 joining
 (NHEJ); production 
of 
a 
non‐functional 
protein; selective 
growth
 advantage; ZFN-mediated gene 
disruption; protection from HIV-1 
infection; humanized
 mouse 
model
 of 
HIV 
infection; adoptive
 transfer; ex 
vivo 
modification
 of 
CD4+
T
cells; HIV‐resistant
 population; viral load; CD4 count; human
 hematopoietic 
stem 
cells 
(HSCs); combined
 disruption
 of
 both 
CCR5 
and 
CXCR4; Phase 
I
 human 
clinical 
trial; permanently 
modified
 cells

Access

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Rights Management

Student author/s retain copyright to this work. Through online submission process, author/s granted Carleton College the non-exclusive rights to preserve this work as part of Carleton's academic history and to use it for teaching purposes and/or institutional research & assessment.

Student Work Completed Date

2013-02-13

Format

application/pdf

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