Zincâ€© Finger â€©Nucleases:â€© Theâ€© Keyâ€© to â€©CCR5 â€©Gene â€©Disruptionâ€© andâ€© Consequent â€©HIV â€©Eradication
Date of Graduation
Date of Submission
Tue, 26 Feb 2013 06:36:20 GMT
Other Department or Program
Mitra, Raka ; Walser-Kuntz, Debby
Category of Work
Group or Individual
Bachelor of Arts
Components of Work
Identifier (Includes All Files and Enter All Their Files Name)
Zinc finger nuclease; sequence â€©specificâ€© endonuclease; CCR5 co-receptor; CXCR4 co-receptor; CCR5 gene disruption; humanâ€© immunodeficiency â€©virusâ€© (HIV); gene therapy; genome editing; HIV-1 M-tropic virus; CD4+ T cells; hematopoieticâ€© stemâ€© cellâ€© transplantationâ€© (SCT); CCR5Î”â€©32 â€©homozygous mutation; zinc finger protein; FokI â€©restrictionâ€© enzyme; modular assembly; oligomerized â€©poolâ€© engineering â€©(OPEN); siteâ€specific â€©doubleâ€strandedâ€© break; nonâ€homologousâ€© endâ€© joiningâ€© (NHEJ); production â€©of â€©a â€©nonâ€functional â€©protein; selective â€©growthâ€© advantage; ZFN-mediated gene â€©disruption; protection from HIV-1 â€©infection; humanizedâ€© mouse â€©modelâ€© of â€©HIV â€©infection; adoptiveâ€© transfer; ex â€©vivo â€©modificationâ€© of â€©CD4+â€©Tâ€©cells; HIVâ€resistantâ€© population; viral load; CD4 count; humanâ€© hematopoietic â€©stem â€©cells â€©(HSCs); combinedâ€© disruptionâ€© ofâ€© both â€©CCR5 â€©and â€©CXCR4; Phase â€©Iâ€© human â€©clinical â€©trial; permanently â€©modifiedâ€© cells
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